Association of hyperuricemia and dyslipidemia in primigravida with preeclampsia during third trimester of gestation at tertiary care hospital

Abstract

Introduction: It is still difficult to identify women who are more likely to develop preeclampsia, even after decades of research into the condition. Determining whether women are "at-risk" is a crucial goal because a marker that identified high-risk women would enable greater surveillance in secondary care, recruiting for studies of possible therapeutic drugs, accurate diagnosis, and prompt action when issues arise. Predicting preeclampsia in women with underlying medical disorders would also be beneficial for tailored therapy.

Objective:To determine the association of hyperuricemia and dyslipidemia with pre-eclampsia in primigravida.

Materials & Methods: A descriptive cross-sectional study was conducted in Chemical Pathology section, Sheikh Zayed Hospital, Rahim Yar Khan, from June 15, 2023, to December 16, 2023, on primigravida aged 18-35 years in their third trimester attending OPD and Indoor Gynecology Department of the hospital. Patients with alreadynown diabetes, gestational diabetes mellitus, chronic hypertension, HBV, HIV, chronic obstructive pulmonary disease (COPD), using aspirin, corticosteroids, and antihypertensive medication were excluded. Lipid profile and uric acid were estimated in preeclampsia and normal pregnancy and results compared between the groups. SPSS 23 was used for data analysis and p≤0.05 was taken as statistically significant.

Results: Mean serum cholesterol in study subjects with preeclampsia was 260.97±36.74mg/dl, mean serum triglyceride was 248.88 ± 34.55mg/dl, mean serum HDL-c was 37.57 ± 5.17mg/dl, and mean LDL-c was 160.06 ± 27.85mg/dl. The difference of mean serum cholesterol, triglyceride, HDL-c, LDL-c was found statistically significant with p value <0.05. Mean serum uric acid level was found higher in preeclampsia as compared to normal pregnancy with statistically significant difference (p= 0.0001).

Conclusion: Hyperuricemia and dyslipidemia were found as significant biochemical abnormalities in females with preeclampsia when compared to normal pregnancy.