A rare case of Common Variable Immunodeficiency presenting with recurrent infections and lung abscess in a young female
Common Variable Immunodeficiency in a young female with recurrent infections
DOI:
https://doi.org/10.52442/jrmi.v12i2.1155Keywords:
Common Variable Immunodeficiency, Lung Abscess, Primary Immunodeficiency, Recurrent Respiratory InfectionsAbstract
Common Variable Immunodeficiency Syndrome (CVID) is a rare primary immunodeficiency characterized by low immunoglobulin levels, recurrent infections, and an increased risk of pulmonary complications. Early diagnosis is crucial to prevent morbidity and mortality. We report a case of a 21-year-old female presenting with recurrent respiratory infections and a right-sided lung abscess. She had a history of pulmonary tuberculosis (TB) and recurrent sinus infections. CT Chest demonstrated cavitary lung lesions consistent with abscess formation. Laboratory investigations revealed significantly reduced immunoglobulin levels, leading to a diagnosis of CVID. This case highlights the importance of recognizing underlying immune deficiencies in patients with recurrent infections.
References
Løken RØ, Fevang B. Cellular immunity in COVID-19 and other infections in common variable immunodeficiency. Front Immunol. 2023 Apr 26;14:1124279. DOI: 10.3389/fimmu.2023.1124279.
Cunningham-Rundles C, Casanova J-L, Boisson B. Genetics and clinical phenotypes in common variable immunodeficiency. Front Genet. 2024;14:1272912. DOI: 10.3389/fgene.2023.1272912
Ameratunga R, Edwards ESJ, Lehnert K, Leung E, Woon ST, Lea E, Allan C, Chan L, Steele R, Longhurst H, Bryant VL. The Rapidly expanding genetic spectrum of common variable immunodeficiency–like disorders. J Allergy Clin Immunol Pract. 2023 Jun;11(6):1646–1664. DOI: 10.1016/j.jaip.2023.01.048. Epub 2023 Feb 14. PMID: 36796510.
Cunningham-Rundles C. Common variable immune deficiency: case studies. Blood. 2019 Nov 21;134(21):1787–1795. DOI: 10.1182/blood.2019002062. PMID: 31751486; PMCID: PMC6872959.
Ghafoor A, Joseph SM. Making a Diagnosis of Common Variable Immunodeficiency: A Review. Cureus. 2020;12(1):e6711. DOI: 10.7759/cureus.6711.
Noor N, Ghori M, Molani RA, Ibrahim MN. Suspected Pediatric-Onset Common Variable Immune Deficiency in a Seven-Year-Old Female With Pulmonary Manifestations. Cureus. 2022;14(9):e29703. DOI: 10.7759/cureus.29703.
Tam JS, Routes JM. Common variable immunodeficiency. Am J Rhinol Allergy. 2013 Jul–Aug;27(4):260–265. DOI: 10.2500/ajra.2013.27.3899. PMID: 23883805; PMCID: PMC3901442.
Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B, et al. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood. 2008 Jul 15;112(2):277–286. DOI: 10.1182/blood-2007-11-124545.
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