Incidence of postoperative wound infection in diabetic versus non-diabetic patients following clean surgical procedures: a cross-sectional study
DOI:
https://doi.org/10.52442/jrmi.v12i1.1020Keywords:
Clean Surgical Procedures, Diabetes Mellitus, Glycemic Control, Postoperative Complications, Surgical Wound InfectionAbstract
Introduction: Surgical site infection (SSI) is among the most common hospital-acquired infections, contributing to delayed wound healing, prolonged hospital stays, and increased healthcare costs. Patients with diabetes mellitus are at a higher risk of developing SSIs due to impaired immunity and delayed tissue repair.
Objectives: To determine the incidence of postoperative wound infection in diabetic and non-diabetic patients undergoing clean surgical procedures and to compare the severity and pattern of infection between the two groups.
Materials and Methods: This cross-sectional analytical study was conducted in in the Federal Government Polyclinic Hospital, Islamabad Pakistan. Patients (n=30) were divided equally into diabetic (n=150) and non-diabetic (n=150) groups. Patients aged 20–70 years undergoing clean surgical procedures were enrolled. Baseline demographics, operative details, and postoperative outcomes were documented. Patients were assessed for SSI on postoperative days 1, 7, and 28. Data were analyzed using SPSS version 26, with a p-value ≤ 0.05 considered statistically significant.
Results: The mean age was 49.8 ± 10.2 years in diabetics and 47.6 ± 9.5 years in non-diabetics (p=0.132). The overall SSI rate was 20.0% in diabetics versus 7.3% in non-diabetics (p=0.002). Infection rates were significantly higher among diabetics on days 7 (p=0.037) and 28 (p=0.006), respectively.
Conclusion: Diabetic patients undergoing clean surgical procedures are at a significantly higher risk of SSIs. Strict perioperative glycemic control and vigilant postoperative monitoring are essential to minimize infection risk.
References
Ahuja S, Peiffer-Smadja N, Peven K, White M, Leather AJM, Singh S, et al. Use of feedback data to reduce surgical site infections and optimize antibiotic use in surgery: a systematic scoping review. Ann Surg. 2022;275(2):e345–e352. Doi: 10.1097/SLA.0000000000004909.
Zhou J, Wang R, Huo X, Xiong W, Kang L, Xue Y. Incidence of surgical site infection after spine surgery: a systematic review and meta-analysis. Spine (Phila Pa 1976). 2020;45(3):208–16. Doi: 10.1097/BRS.0000000000003218.
Shiferaw WS, Aynalem YA, Akalu TY, Petrucka PM. Surgical site infection and its associated factors in Ethiopia: a systematic review and meta-analysis. BMC Surg. 2020;20:107. Doi: 10.1186/s12893-020-00764-1.
Burgess JL, Wyant WA, Abdo Abujamra B, Kirsner RS, Jozic I. Diabetic wound-healing science. Medicina (Kaunas). 2021;57(10):1072. Doi: 10.3390/medicina57101072.
Qamar R, Mahmood K, Pervaiz N, Javed R, Sher F, Tufail I. Comparative study on incidence of post-operative wound infection in diabetic vs non-diabetic patients in clean surgical procedure. Pakistan J Med Res. 2023;62(1):14–18. https://pjmr.org.pk/index.php/pjmr/article/view/416.
Hwang JU, Son DW, Kang KT, Lee SH, Lee JS, Song GS, et al. Importance of hemoglobin A1c levels for the detection of post-surgical infection following single-level lumbar posterior fusion in patients with diabetes. Korean J Neurotrauma. 2019;15(2):150–8. Doi: 10.13004/kjnt.2019.15.e36.
Reich MS, Fernandez I, Mishra A, Kafchinski L, Adler A, Nguyen MP. Diabetic control predicts surgical site infection risk in orthopaedic trauma patients. J Orthop Trauma. 2019;33(10):514–17. Doi: 10.1097/BOT.0000000000001512.
Ganesh GV, Ramkumar KM. Macrophage mediation in normal and diabetic wound healing responses. Inflamm Res. 2020;69(4):347–63. Doi: 10.1007/s00011-020-01328-y.
Holl J, Kowalewski C, Zimek Z, Fiedor P, Kaminski A, Oldak T, et al. Chronic diabetic wounds and their treatment with skin substitutes. Cells. 2021;10(3):655. Doi: 10.3390/cells10030655.
Armstrong DG, Tan T-W, Boulton AJM, Bus SA. Diabetic foot ulcers: a review. JAMA. 2023;330(1):62–75. Doi: 10.1001/jama.2023.10578.
Cheuk N, Worth L, Tatoulis J, Skillington P, Kyi M, Fourlanos S. The relationship between diabetes and surgical site infection following coronary artery bypass graft surgery in current-era models of care. J Hosp Infect. 2021;116:47–52. Doi: 10.1016/j.jhin.2021.07.009.
Beverly JK, Budoff MJ. Atherosclerosis: pathophysiology of insulin resistance, hyperglycemia, hyperlipidemia, and inflammation. J Diabetes. 2020;12(2):102–4. Doi: 10.1111/1753-0407.12970.
Khalid M, Alkaabi J, Khan MAB, Adem A. Insulin signal transduction perturbations in insulin resistance. Int J Mol Sci. 2021;22(16):8590. Doi: 10.3390/ijms22168590.
Arshad S, Rasul A, Batool M, Zukhruf Z, Asad MT. Diabetes and risk of surgical site infection: a narrative review. J Health Rehabil Res. 2024;4(1):567–72. Doi: 10.61919/jhrr.v4i1.500
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Journal of Rehman Medical Institute

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
