Effect of Dapoxetine on intravaginal ejaculatory latency time (IELT) in premature ejaculation: a systematic review


  • Syed Salman Shah Assistant Professor, Khyber Medical College, Peshawar.
  • Syed Hamid Habib Assistant Professor Physiology, Institute of Basic Medical Sciences, Khyber Medical University.
  • Omar Malik Assistant Professor, Khyber Medical University, Peshawar.
  • Muhammad Haris Burki Consultant Sexual Psychiatrist, Lahore.
  • Eemaz Nathaniel Final Professional MBBS Student, Rehman Medical College, Peshawar.


Premature Ejaculation; Systematic Review; Serotonin; Dopamine


Introduction: The safety and efficacy of Dapoxetine for the treatment of premature ejaculation (PE) is still controversial. Thus, we decided to conduct a systemic review to determine the sufficiency of conclusions.
Objective: To evaluate the efficacy and safety of Dapoxetine in the treatment of patients with premature ejaculation and assess the reliability of the findings.
Materials & Methods: Four original articles were identified by a systematic search of MEDLINE Database. Those articles were included in the review with clear mention of PE and Dapoxetine in titles and abstracts.
Results: The mean IELT score recorded at baseline of each study is much lower than recorded after treatment with Dapoxetine. The difference between baseline IELT and post treatment IELT is significant in all studies.
Conclusion: The evidence suggests that Dapoxetine may be a safe and effective drug for patients with PE.