Association of oxidative stress with lipid profile in various stages of Psoriasis
Keywords:Oxidative Stress; Psoriasis; Lipid Profile
Introduction: Along with specific clinical features reported in the autoimmune disease Psoriasis, biochemistry reveals abnormal lipid profiles, reduced anti-oxidant enzyme activity, and lipid peroxidation, features that may promote atherogenesis in these patients.
Objective: To ascertain the association of oxidative stress in terms of extent of lipid peroxidation with lipid profile in various stages of psoriasis.
Materials & Methods: The present case control study was carried out in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi from April 2015 to December 2015. One hundred and twenty patients of psoriasis were included in the study and grouped as mild, moderate, or severe; their data were compared with the data of healthy control group (n=40). Blood was taken from all the subjects, serum separated and analyzed for lipid profile including total cholesterol, triglycerides, high-density lipoproteins (HDL) and low-density lipoproteins (LDL). The extent of lipid peroxidation and antioxidant status were determined by assaying the levels of Malondialdehyde (MDA) and Superoxide Dismutase (SOD) respectively by ELISA. Statistical analysis was done by SPSS software version-16.
Results: A significant increase in the serum level of triglycerides (TG), total cholesterol and LDL was seen in psoriatic patients as compared to controls whereas HDL was significantly low in psoriatic groups. The patients of psoriasis as a whole were having higher levels of MDA as compared to control subjects although a significant increase was found only in severe disease group (p<0.01). Similarly, the psoriasis patients had low levels of SOD compared to controls, but a significant decrease was observed only in severe disease group (p<0.004).
Conclusion: It is likely that imbalance in oxidant-antioxidant system plays role in the etiology of psoriasis.